Federal Institute for Population Research

Mortality Follow-Up of the German National Cohort - Accompanying Research

Content and Objectives

With the third funding phase and publication of the first processed mortality follow-up data for research, Research Group 3.3 "Mortality Follow-Up of the NAKO Health Study" is also taking up the accompanying research. Four focal points can be identified. The first is a detailed descriptive description of the subpopulation of deceased persons in the NAKO study population. Of particular importance here will be the identification and measurement of selection bias in the study population compared to the original population. Similar approaches can also be used to analyse other data sets relating to the original population. To this end, the BiB team of the NAKO was granted the evaluation project "The first 3000 Deaths in the German National Cohort Study - a Descriptive Report" under the procedure code "NAKO-819". A second focus is on causal analyses of deaths in the NAKO study population. This aims to identify risk factors in selected subgroups for general and selected specific mortality in the NAKO population. At a later stage, health outcome analyses could also be carried out in the presence of certain risk factors and certain co-morbidities. A third focus is a critical evaluation of the methods of mortality follow-up projects in cohorts and the development of proposals for improving mortality statistics. A fourth focus, in the context of collaboration with the Global Burden of Disease Study (GBD), is the global recording of general and specific mortality in the event of poor data availability.

Data and Methods

In addition to descriptive methods and estimation methods, both embedded case-control studies and various survival analyses are aimed at for the causal analyses.

Duration

since 05/2023

Partners

Global Burden of Disease Study (GBD)

Funding

BiB's own funding, Federal Ministry of Education and Research (BMBF), federal states (except Rhineland-Palatinate, Hesse, Thuringia), Helmholtz Association

Publications

GBD 2019 Chronic Respiratory Diseases Collaborators (2023):

EClinicalMedicine 59:101936.

GBD 2019 Diabetes Mortality Collaborators (2022):

The Lancet Diabetes & Endocrinology 10(3): 177–192.

Werdecker, Andrea; Mueller, Ulrich (2021):

Bruno Masquelier et al. Global, regional, and national mortality trends in youth aged 15–24 years between 1990 and 2019: a systematic analysis. The Lancet Global Health 9(4): e409–e417.

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